Associate Professor Benjamin Thierry
Tel: +61 8 8302 3689
Fax: +61 8 8302 3683
Associate Research Professor
BEng INP Grenoble, France MSc Ecole Polytechnique Montreal, Canada PhD McGill, Canada
www.bionanoengineering.com for more information.
Benjamin Thierry was educated in France, obtaining his Engineering degree in Chemical Physics and Materials Sciences at the Institut National Polytechnique de Grenoble (INPG). He then moved to Montreal to complete his Masters at the Ecole Polytechnique de Montreal in the Institute of Biomedical Engineering. Benjamin obtained his PhD in 2004 in the Department of Biomedical Engineering at McGill University in Montreal, Canada under the supervision of Prof Tabrizian, Prof Winnik and Prof Mehri. His work involved the development of new strategies for revascularization procedures based on surface modification of endovascular devices. Benjamin joined The Wark in May 2004.
The main aim of Associate Professor Benjamin Thierry's interdisciplinary research program is to develop and implement novel cancer biodiagnostic and prognostic technologies. A major aspect of his translational research is on the design of solid state biosensing approaches based on cutting edge nanotechnology principles to isolate and/or detect rare cells and cancer biomarkers from biological samples such as blood and resected tissues. In close collaborations with clinicians and cancer biologists, his group also aim to achieve mechanistic understanding of the penetration of therapeutic and diagnostic agents inside tumour tissues and to translate this fundamental understanding into more efficient diagnostic and therapeutic approaches.
NH&MRC 1045841 Thierry B., Wang D., Nie G., Kempson I. 2013-2015, $398,703 Title: Nanomedicines Immunotargeting: Hitting the Target or Lost In Translation?
NHMRC 1047576. Wormald P.J., Prestidge C., Thierry B. 2013-2015, $584,362 Title: A novel nitric oxide-based treatment for recalcitrant Staphylococcus aureus-associated chronic rhinosinusitis.
NSW Cancer Council. Thomson S. and Thierry B. 2011-2013, $95,000; Sentinel Lymph Node Biopsy In Oesophageal Adenocarcinoma - Improving Staging Accuracy & Optimising Treatment.
NH&MRC 631940 Career Development Award. Thierry B. 2010-2014, $377,000; Title: Functional nanoparticles: towards novel advanced cancer diagnostic, prognostic and therapeutic strategies.
Clive and Vera Ramaciotti Foundation Equipment Grant. Thierry B. et al., $65,000.
NH&MRC 631939. Thierry B., O'Doherty C., Ralston J. 2010-2013, $407,125; Title: Microfabricated devices: a significant advance for the detection and molecular analyses of circulating cancer cells?
Career peer-reviewed articles and book chapters: 52; 74% as first or senior author
'h' index: 17; Total citations: ~1150 (March 2014); Average Impact factor: 5.7
Liu, T., Chien C.-C., Parkinson L., Thierry B.*, Microfabricated Concave Microwells for Long Term On-Chip Culture of Multicellular Tumour Spheroids and Drug Assays. ACS Applied Materials & Interfaces (Accepted April 2014)
Liu, T., Winter M., Thierry B.*, Quasi-Spherical Microwells for Long Term Culture of Multicellular Spheroids and On-Chip Assays on Superhydrophobic Substrates. Biomaterials (Accepted April 2014)
Tran P.D., Wolfrum B., Stockmann R., Offenhausser A., Thierry B.* Fabrication of locally confined silicon nanowires. J Mat Chem C. (Accepted April 2014).
Jardeleza C., Rao S., Thierry B., Gajjar P., Vreugde S., Prestidge C.A., Wormald P.J. Liposome-encapsulated ISMN: a Novel Nitric Oxide-Based Therapeutic Agent against Staphylococcus aureus Biofilms. Plos one. DOI: 10.1371/journal.pone.0092117 (2014) (IF 3.75)
Winter M., Gibson R., Ruszkiewicz A., Thompson S.K., Thierry B.* Beyond Conventional Pathology: Towards Pre- and Intra-operative Lymph Node Staging. International Journal of Cancer. DOI: 10.1002/ijc.28742 (2014) (IF 6.2)
Sivanathan K.N., Canales D.-R., Gronthos S., Thierry B., Coates P.T. Interferon-gamma modification of Mesenchymal Stem Cells: a strategy to enhance immunosuppression in allotransplantation. Stem Cells Reviews and Report. DOI 10.1007/s12015-014-9495-2 (2014) (IF 4.5)
Mejard R., Griesser H.J., Thierry B.*, Optical Biosensing for Label-free cellular studies, Trends in Analytical Chemistry. 53, 178?186 (2014) (IF 6.4)
Tran P.D., Wolfrum B., Stockmann R., Offenhausser A. and Thierry B*. Wafer-Scale Fabrication of Ultra-Thin Silicon Nanowire Devices. IEEE explore transaction 10.1109/NANO.2013.6720826 405 - 409 (2013)
Cousin A, Thompson S.K., Wedding A.B., Thierry B.* Clinical relevance of novel imaging technologies for sentinel lymph node identification and staging. Biotechnology Advances doi: 10.1016/j.biotechadv.2013.10.011 (2013) (IF 9.6)
Mejard R., Dostalek J., Huang C.-J., Griesser H.J., Thierry B., Tuneable and robust long range surface plasmon resonance for biosensing applications, Optical Materials. 35(12): p. 2507-2513 (2013) (IF 1.9)
Liu T., Cousins A., Chien C.-C., Kempson I., Thompson S., Hwu Y., Thierry B.* Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node. Cancer Letters 328(2):271-7 (2013). (IF 4.25)
Liu M., Thierry B.*, A Solution to the PEG Dilemma: Efficient Bioconjugation of Large Gold Nanoparticles for Biodiagnostic Applications using Mixed Layers. Langmuir, 2012, 28 (44), pp 15634?15642
Thierry B*. Griesser H.J. Dense PEG Layers for Efficient Immunotargeting of Nanoparticles to Cancer Cells. Journal of Materials Chemistry. 22, 8810-8819 (2012) (A, IF 5.1)
Thierry B., Textor M. Nanomedicine In Focus: Opportunities and Challenges Ahead. BioInterphase (IF 3.5) 7(19) (2012)
David A. Beattie, Audrey Beaussart, Agnieszka Mierczynska-Vasilev, Sarah L. Harmer, Benjamin Thierry, Ljiljana Puskar, and Mark Tobin; Letter Synchrotron FTIR Microscopy of Langmuir-Blodgett Monolayers and Polyelectrolyte Multilayers at the Solid-Solid Interface. Langmuir 2012, 28 (3), 1683?1688
Thierry B., Winnik F. LbL. In Multilayer Thin Films. Gero Decher and Joe Schlenoff, Wiley-VCH Verlag GmbH (invited) 2012
Fong W.-K., Hanley T.L., Thierry B., Kirby N., Waddington L.J., Boyd B.J. Controlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiation. Langmuir (2012), 28 (40), 14450-14460
Kurkuri M.D., Al-Ejeh F., Shi J.Y., Palms D., Prestidge C., Griesser H.J., Brown M.P., Thierry B*. Plasma functionalized PDMS microfluidic chips: towards point-of-care capture of circulating tumor cells. Journal of Materials Chemistry 21, 8841-8848 (2011)
Thierry B., Majewski P. Magnetic Nanoparticles, In 2nd edition of The Encyclopedia of Nanoscience and Nanotechnology, Hari Singh Nalwa, American Scientific Publisher (2011)
Garvey M., Griesser S.S., Griesser H.J., Thierry B., Nussio M.R., Shapter J.G., Ecroyd H., Giorgetti S., Bellotti V., Gerrard J.A., Carver J.A. Enhanced molecular chaperone activity of the small heat-shock protein αB-crystallin following covalent immobilization onto a solid-phase support. Biopolymers. 95(6) (2011)
Thierry B.*, Kurkuri M., Shi J.Y., Lwin L.E.M.P., Palms D. Herceptin functionalized microfluidic polydimethylsiloxane devices for the capture of human epidermal growth factor receptor 2 positive circulating breast cancer cells. Biomicrofluidic. 4(3), 032205 (2010)
Vreuls C., Zocchi G., Thierry B., Garitte G., Griesser S.S., Archambeau C., Weerdt C.Vd, Martial J., Griesser H.J. Prevention of bacterial biofilms by covalent immobilization of peptides onto plasma polymer functionalized substrates. J. Mat. Chem. 20, 8092-8098 (2010)
Losic D, Yu Y, Aw MS, Simovic S, Thierry B, Addai-Mensah J. Surface functionalisation of diatoms with dopamine modified iron-oxide nanoparticles: toward magnetically guided drug microcarriers with biologically derived morphologies. Chemical Communication. 46(34):6323-5 (2010)
Fong W.-K., Hanley T.L., Thierry B., Kirby N., Boyd B.J. Plasmonic nanorods provide reversible control over nanostructure of self assembled drug delivery materials. Langmuir 26(9), 6136?6139 (2010)
Truong M.Y., Dutta N.K., Choudhury N.R., Kim M., Elvin C.M., Hill A.J., Thierry B., Vasilev K. A pH-responsive interface derived from resilin-mimetic protein Rec1-resilin. Biomaterials. 31(15), 4434-4446 (2010)
Thierry B*, Al-Ejeh F., Khatri A., Yuan Z., Russell P.J., Ping S., Brown M.P., Majewski P. Multifunctional Core-Shell Magnetic Cisplatin Nanocarriers. Chemical Communication 47, 7348-7350 (2009)
Thierry B*. Drug Nanocarriers and Functional Nanoparticles: Applications in Cancer Therapy. Current Drug Delivery (Invited review). 6(4), 391-403 (2009)
Thierry B.*, Ng J., Krieg T., Griesser H.J. A Robust Procedure for the Functionalization of Gold Nanorods and Noble Metal Nanoparticles. Chemical Communication 13, 1724-1726 (2009)
Thierry B.*, Al-Ejeh F., Brown M., Majewski P., Griesser H.J. Immunotargeting of advanced functional nanostructures for cancer diagnosis and treatment. Advanced Materials 21, 541-545 (2009)
Al-Ejeh F., Darby J.M., Thierry B., Brown M. Modulating the ratio of metal chelator-antibody conjugation to optimize radioimmunoscintigraphy and radioimmunotherapy applications. Nuclear Medicine and Biology 36(4), 395-402 (2009)
Majewski P., Thierry B. Functionalized magnetite nanoparticles - synthesis, properties, and bio-applications, In Particulate Systems in Nano- And Biotechnologies, Wolfgang Sigmund, Taylor and Francis, 331-352 (2009)